The Global Oligonucleotide Synthesis Market has been estimated to reach USD 6.5 billion in 2021 and is projected to grow at a CAGR of 17.6% during the forecast period from 2021 to 2030. Oligonucleotides are highly suitable for research, disease diagnosis, therapy, pharmacology, drug discovery, farming, etc. In various biological and forensic applications, the presence of a particular target DNA sequence can be identified by oligonucleotides.
Synthetic oligonucleotides of a single stranded fragment of DNA are short stretches, assembled through chemical synthesis. The primary reason for this revolution is the simultaneous development of techniques for fast and effective oligonucleotide synthesis and molecular biology. Researchers also use oligonucleotides to produce more efficient greener chemical synthesis.
The production of special enzymes can be achieved by combining oligonucleotides into long fragments, encoding synthetic genes, bacteria, or leaven cells (a type of protein). Oligonucleotides can treat a variety of medical conditions. Through targeting, manipulation, muteness, and/or modulation of dysfunctional genes, they allow the therapy to develop. Ionis pharmaceuticals has especially dedicated itself to the oligonucleotides therapies, especially antisense oligonucleotide (ASO) therapy.
The growth of the market in oligonucleotide synthesis stems from advances in the synthesis of oligonucleotides and an increase in synthetic biology research work. Recent progress on synthesis techniques has led to an economical and rapid synthesis of oligomers. In addition, oligonucleotide synthesis has revolutionized high-performance plant development, new protective amino groups, and more efficient connective agent development. The development of oligonucleotide product for therapeutic and diagnostic purposes has supported the development of microarrays.
Many biological ligands are used to test oligonucleotide conjugates, which are being increasingly used in the diagnosis of a variety of genetic disorders. Due to the progress of oligonucleotide synthesis, an increase in the production and cost of oligonucleotide synthesis has occurred.
Furthermore, progress in enzyme failure correction technology has reduced the incidence of synthesis errors. This has supported the growth of the global oligonucleotide synthesis market. The market growth of oligonucleotide synthesis is projected to have a positive impact on personalized medicines during the forecast period. Personalized medicine is tailored to each patient's needs and preferences. Oligonucleotide synthesis helps provide tailored solutions to patients.
The use of custom medicines to treat rare diseases is possible with the synthesis of oligonucleotides. Patients will be properly treated and diagnosed with advances in oligonucleotide synthesis. A growing focus on personalized medicine will, therefore, offer market players a lot of opportunities.
Global Oligonucleotide Synthesis Market, By Product
By product, the global oligonucleotide synthesis market has been segmented into oligonucleotide, and reagents and equipment. In 2021, the oligonucleotide-based drug sector has captured the greatest share in the market for oligonucleotides synthesis. The increasing numbers of FDA-approved medicines and an extensive clinical pipeline of oligonucleotide-based medicines should drive the growth of this segment in the next few years.
Global Oligonucleotide Synthesis Market, By Type
By type, the global oligonucleotide synthesis market has been segmented into custom oligos and predesigned oligos. Customized synthesis of oligonucleotides is growing worldwide. As research and development in the field of synthetic biology are growing rapidly, the demand for high-end tailored oligos is rising.
An increase in demand for quality improvisation to remove impurities and enhance its effectiveness has resulted in an increasing use of synthetic oligonucleotides in industry and university research. However, approximately 50% of the total cost of production is covered by the cost of cleaning, and continuous research is underway to identify upgraded methods to achieve the desired results. Examples include the implementation of non-chromatographic treatment methods and many internal modifications.
Global Oligonucleotide Synthesis Market, By Application
By application, the global oligonucleotide synthesis market has been segmented into therapeutic application, diagnostic, research, and others. In 2021, oligonucleotide synthesis has been the most important part of the market in the field of therapeutic applications. The growing use of oligos for the treatment of neurological diseases, contagious disorders, and rare genetic disorders (such as antisense oligos and siRNA) is expected to stimulate market growth.
Global Oligonucleotide Synthesis Market, By End User
By end user, the global oligonucleotide synthesis market has been segmented into academic research institutes, pharmaceutical and biotechnology companies and diagnostic laboratories. In 2021, academic research institutes has captured the largest share of the. Growth of this market is mainly due to the high demands for oligonucleotide medicines in hospitals where patients with rare diseases, neurological disorders, and infectious diseases are hospitalized.
Global Oligonucleotide Synthesis Market, By Region
By region, the global oligonucleotide synthesis market is segmented as North America, Europe, Asia Pacific, Middle East & Africa, and South America. In 2021, North America has captured the largest share in this market. This can be attributed to increased life-sciences research and development activities, as well as a greater focus on improving healthcare safety and quality. A growing demand for high-quality reproducible research instruments and a greater focus on personalized therapies development will also drive the growth of this regional market. Another important factor contributing to the large share of this region in the global market is the presence of several key global players in North America.
COVID-19 Impact on Oligonucleotide Synthesis Market
The QMI team has closely monitored the impact of COVID-19 on the global oligonucleotide synthesis market, and it is observed that the demand for oligonucleotide synthesis has increased during the pandemic time. It is anticipated to grow at a healthy pace from mid-2021. To control the pandemic, many countries across the globe have enforced strict lockdown norms, which have hampered all kinds of business activities.
Some Major Findings of the Global Oligonucleotide Synthesis Market Include:
Market Segmentation:
By Product
By Type
By Application
By End User
By Region
Detailed scope covering all the major segments in the market
In line data validations to ensure data precision
Market recommendations supporting decision making processes
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